Impact of polyols on Oral microbiome of Estonian schoolchildren

• DOI: 10.1186/s12903-019-0747-z
• Publication Date: 2019-04-18T09:07:39Z
• Authors: Jelena Štšepetova; Jaak Truu; Riina Runnel; Rita Nõmmela; Mare Saag; Jana Olak; Hiie Nõlvak; Jens-Konrad Preem; Kristjan Oopkaup; Kaarel Krjutškov; Eino Honkala; Sisko Honkala; Kauko Mäkinen; Pirkko-Liisa Mäkinen; Tero Vahlberg; Joan Vermeiren; Douwina Bosscher; Peter de Cock; Reet Mändar
• Keywords: Erythritol; Fusobacteria; Sugar alcohol; Oral Microbiome; Fusobacterium

Oral microbiome has significant impact on both oral and general health. Polyols have been promoted as sugar substitutes in prevention of diseases. We aimed to reveal the effect candies containing erythritol, xylitol or control (sorbitol) salivary microbiome.Ninety children (11.3 ± 0.6 years) consumed during 3 years. Microbial communities were profiled using Illumina HiSeq 2000 sequencing real-time PCR.The dominant phyla saliva Firmicutes (39.1%), Proteobacteria (26.1%), Bacteroidetes (14.7%), Actinobacteria (12%) Fusobacteria (6%). The erythritol group significantly differed from that other groups. Both reduced number observed bacterial phylotypes comparison group. relative abundance genera Veillonella, Streptococcus Fusobacterium higher while Bergeyella lower after intervention when comparing with control. lowest prevalence caries-related mutans streptococci corresponded clinical caries markers group.Daily consumption a specific influence composition schoolchildren. Erythritol is associated levels experience.ClinicalTrials.gov Identifier NCT01062633.