Evaluating the performance of a low-cost mobile phone attachable microscope in cervical cytology

• DOI: 10.1186/s12905-020-00902-0
• Publication Date: 2020-03-25T07:03:07Z
• Authors: Ali Naqvi; Niti Manglik; Ellen Dudrey; Cynthia Perry; Zuber D. Mulla; Jorge L. Cervantes
• Keywords: Squamous intraepithelial lesion; Cohen's kappa; Kappa; Confusion; Cervical screening

Cervical cancer remains a global health problem especially in remote areas of developing countries which have limited resources for cervical screening. In this study, we evaluated the performance low-cost, smartphone attachable paper-based microscope when used classifying images cytology.Cervical cytology samples included: 10 Normal, Low-grade squamous intraepithelial lesion (LSIL), High-grade (HSIL), and Malignant Pap Smears. The agreement between conventional microscopy vs. Foldscope imaging was calculated using weighted kappa coefficient. A confusion matrix created with three classes: LSIL, HSIL/malignant, to evaluate by calculating accuracy, sensitivity, specificity.We observed statistic 0.68 agreement. This translates into substantial cytological classifications microscopy. accuracy 80%, sensitivity specificity 85 90% HSIL/Mal category, 80 83.3%, 70 96.7% Normal.This study highlights usefulness cytology, demonstrating it has Its use could improve cytologic interpretations underserved and, thus, quality Improvements existing limitations device, such as ability focus, potentially increase its accuracy.