Clinical features and recurrence of Corynebacterium kroppenstedtii infection in patients with mastitis

• DOI: 10.1186/s12905-022-01859-y
• Publication Date: 2022-07-06T08:04:05Z
• Authors: Weiwei Zeng; Sixian Lao; Wenbin Jia; Xintian Shen; Lijuan Wu; Yan Zhong; Feiling Wang; Guoping Zhong
• Keywords: 0301 basic medicine; Corynebacterium kroppenstedtii; Cefuroxime; Suppuration; Corynebacterium Infections; Research; Clinical features; Gynecology and obstetrics; Corynebacterium; Triamcinolone Acetonide; Anti-Bacterial Agents; 3. Good health; Treatment; 03 medical and health sciences; Granulomatous lobular mastitis; Antibiotics; RG1-991; Humans; Female; Granulomatous Mastitis; Public aspects of medicine; RA1-1270

Abstract Background Few studies have investigated the differences in clinical features of patients with mastitis following Corynebacterium kroppenstedtii infection, and most focused on the bacterial antimicrobial susceptibility, detection methods and therapy.

Methodology There were 133 patients with mastitis infected by C. kroppenstedtii between August 2016 and September 2019. C. kroppenstedtii was identified using mass spectrometry. The demographics, clinical diagnosis, laboratory test results of different types of mastitis combined with bacillus infection, and the effects of different treatments in reducing recurrence were compared.

Results The incidence of pus following C. kroppenstedtii infection was higher in patients with non-granulomatous lobular mastitis (NGLM; 56.6%) than in those with granulomatous lobular mastitis (GLM; 33.3%; χ2 = 7.072, p = 0.008). While C-reactive protein (CRP) was higher in the GLM group (12.50 mg/L) than in the NGLM group (6.05 mg/L; Z = − 2.187, p = 0.029). Treatment with local lavage (triamcinolone acetonide) and antibiotics (cefuroxime) showed a recurrent rate of 25.9% in C. kroppenstedtii infection.

Conclusion Increased pus, large masses, and an elevated CRP level may occur in patients with mastitis infected by C.kroppenstedtii. These clinical features may guide the determination of the bacterial infection in patients with mastitis. Combining an antibiotic with a triamcinolone acetonide lavage, preferably cefuroxime, may reduce the recurrence.