Global, regional, and national burden of anxiety disorders during the perimenopause (1990–2021) and projections to 2035

• DOI: 10.1186/s12905-025-03547-z
• Publication Date: 2025-01-07T10:24:45Z
• Authors: Ying Zhang; Ting-Ting Hu; Yong-Ran Cheng; Zhi-Fen Zhang; Jun Su
• Keywords: GBD; Research; RG1-991; Gynecology and obstetrics; Average percent change; Public aspects of medicine; RA1-1270; Disability-adjusted life years; Perimenopause; Anxiety disorders

Abstract Purpose Perimenopause is associated with an increased risk of anxiety disorders, largely due to hormonal changes affecting the body’s regulatory feedback mechanisms. This study aims provide a comprehensive analysis global burden disorders among perimenopausal women. Methods Data from 2021 Global Burden Disease (GBD) database were utilized assess disability-adjusted life years linked perimenopause. We calculated trends using estimated average percent change, and future projections made Bayesian age–period–cohort model estimate year for 2022 2035. Results Between 1990 2021, age-standardized rate women 625.51 (95% uncertainty interval: 429.1–891.09) 677.15 469.45–952.72), indicating rising trend change 0.081 confidence 0.0043–0.143). Regional differences noted, disorder burdens varying across areas different sociodemographic index levels. Projections suggest that by 2035, in will rise 1,180.43 per 100,000, 40.67% increase compared Conclusion The during perimenopause growing concern, significant anticipated coming years. Targeted prevention intervention strategies are urgently needed mitigate this improve mental health outcomes