Significance of serum ferritin as a prognostic factor in advanced hepatobiliary cancer patients treated with Korean medicine: a retrospective cohort study

• DOI: 10.1186/s12906-018-2240-7
• Publication Date: 2018-06-07T10:55:34Z
• Authors: Anna Song; Wankyu Eo; Sehyun Kim; Bumsang Shim; Sookyung Lee
• Keywords: Univariate analysis; Interquartile range

Advanced hepatobiliary cancers are highly lethal that require precise prediction in clinical practice. Serum ferritin level increases malignancy and high serum is associated with poor survival various cancers. This study aimed to identify whether could independently predict the overall (OS) of patients advanced cancers.The retrospective cohort was performed by reviewing medical records from June 2006 September 2016. The demographic clinicopathological characteristics as well biochemical markers were evaluated at initiation Korean medicine (KM) treatment. OS calculated using Kaplan-Meier estimates. Cox proportional hazard model used independent prognostic significance for survival.The median all subjects 5.1 months (range, 0.5-114.9 months). group low levels 7.5 0.7-114.9 months) 2.8 0.5-22.8 months), respectively (P < 0.001). results univariate analysis showed Eastern Cooperative Oncology Group Performance Status (ECOG-PS) = 0.002), tumor type 0.001), prior treatment 0.023), hemoglobin total bilirubin gamma-glutamyl transpeptidase 0.007), albumin 0.013), white blood cell C-reactive protein (CRP) 0.001) significant factors patients' outcome. On multivariate controlling confounding factors, 0.041), CRP 0.010), ECOG-PS 0.018) identified survival.These indicate a valid marker