The protective effect of L-carnitine on testosterone synthesis pathway, and spermatogenesis in monosodium glutamate-induced rats

• DOI: 10.1186/s12906-022-03749-0
• Publication Date: 2022-10-13T12:08:52Z
• Authors: Farhad Koohpeyma; Fatemeh Gholizadeh; Hannaneh Hafezi; Mehri Hajiaghayi; Morvarid Siri; Shaghayegh Allahyari; Mohammad Hasan Ma...; Naeimehossadat As...; Elahe Bayat; Sanaz Dastghaib
• Keywords: Monosodium glutamate; Germinal epithelium; Malondialdehyde

Monosodium glutamate (MSG) is a food ingredient that increasingly used commercially. MSG leads to oxidative stress, consequently suppressing steroid hormone production causes defects in male reproductive system. This study aimed evaluate the effect of L-carnitine as an antioxidant on testicular damage MSG-induced rats.Sixty adult Spargue-Dawley rats were randomly divided into six groups ten follows: control (water), sham (normal saline), (200 mg/kg b.w), (3 g/kg + 100 b.w and L-carnitine), 200 L-carnitine). The treatment was administered by oral gavage for months. Serum levels Malondialdehyde (MDA), Total Anti-oxidant Capacity (TAC), LH, FSH, testosterone, mRNA expressions Star, Cyp11a1, Hsd17b3 genes, histological stereological changes assessed.L-carnitine led significant decrease level MDA rise serum TAC, expression Star Cyp11a1 compared group (p < 0.05). Furthermore, results indicated increment number sexual lineage cells, total volume testis, length, diameter, seminiferous tubules, height germinal epithelium, sperm count, motility 0.05) compare group.The study's findings demonstrated due its anti-oxidant properties, ameliorated abnormalities exposed MSG.