snoRNAs are a novel class of biologically relevant Myc targets

• DOI: 10.1186/s12915-015-0132-6
• Publication Date: 2015-04-15T10:05:31Z
• Authors: Eva K Herter; Maria Stauch; Maria Gallant; Elmar Wolf; Thomas Raabe; Peter Gallant
• Keywords: Small nucleolar RNA; ribosome biogenesis; Chromatin immunoprecipitation

Myc proteins are essential regulators of animal growth during normal development, and their deregulation is one the main driving factors human malignancies. They function as transcription that (in vertebrates) control many growth- proliferation-associated genes, in some contexts contribute to global gene regulation. We combine chromatin immunoprecipitation-sequencing (ChIPseq) RNAseq approaches Drosophila tissue culture cells identify a core set less than 500 target whose salient resides ribosome biogenesis. Among these genes we find non-coding snoRNA large novel class targets. All assayed snoRNAs affected by Myc, them subject direct transcriptional activation both vertebrates. The loss impairs whereas overexpression increases tumor mass model for neuronal tumors. This work shows acts master regulator snoRNP In addition, combination with recent observations involvement cancer, it raises possibility Myc's transforming effects partially mediated this transcripts.