Genome-wide pQTL analysis of protein expression regulatory networks in the human liver

• DOI: 10.1186/s12915-020-00830-3
• Publication Date: 2020-08-10T21:03:03Z
• Authors: Bing He; Jian Shi; Xinwen Wang; Hui Jiang; Hao-Jie Zhu
• Keywords: Proteomics; 0301 basic medicine; Protein expression regulation; Proteome; QH301-705.5; Quantitative Trait Loci; 03 medical and health sciences; Gene Expression Regulation; Liver; Protein-disease interaction; Protein quantitative trait loci; Humans; Gene Regulatory Networks; Biology (General); Research Article; Genome-Wide Association Study

Previous expression quantitative trait loci (eQTL) studies have identified thousands of genetic variants to be associated with gene at the mRNA level in human liver. However, protein often correlates poorly levels. Thus, (pQTL) study is required identify that regulate livers.