Dietary supplementation of Ascophylum nodosum improved kidney function of mink challenged with Aleutian mink disease virus

• DOI: 10.1186/s12917-020-02685-w
• Publication Date: 2020-11-30T16:03:07Z
• Authors: A. Hossain Farid; Nancy J. Smith
• Keywords: 2. Zero hunger; 0301 basic medicine; Veterinary medicine; Aleutian Mink Disease; Aleutian Mink Disease Virus; Creatine; Virus Replication; Animal Feed; Blood Urea Nitrogen; Diet; 3. Good health; 03 medical and health sciences; Ascophylum nodosum; Kidney function; Aleutian mink disease virus; American mink; Mink; SF600-1100; Serum profile; Animals; Female; Viremia; Ascophyllum; Research Article

AbstractBackgroundFeed additives which can ease the negative effects of infection by the Aleutian mink disease virus (AMDV) are of interest to mink farmers. The effects of kelp meal (Ascophylum nodosum) supplementation on immune response, virus replication and blood parameters of mink inoculated with AMDV were assessed. AMDV-free black mink (n = 75) were intranasally inoculated with a local strain of AMDV and fed a commercial pellet supplemented with kelp meal at the rates of 1.5% or 0.75% of the feed or were kept as controls (no kelp) for 451 days. Blood was collected on days 0 (pre-inoculation), 31, 56, 99, 155, 366 and 451 post-inoculation (dpi).ResultsNo significant difference was observed among the treatments for the proportion of animals positive for antibodies against the virus measured by the counter-immunoelectrophoresis (CIEP), viremia measured by PCR, antibody titer measured by quantitative ELISA, total serum protein measured by a refractometer or elevated levels of gamma globulin measured by iodine agglutination test at the sampling occasions. At the termination of the experiment on 451 dpi, there were no differences among treatments for antibody titer measured by CIEP, total serum protein, albumin, globulins, albumin:globulin ratio, alkaline phosphatase, gamma-glutamyl transferase, and proportions of PCR positive spleen, lymph node or bone marrow samples, but blood urea nitrogen and creatine levels were significantly lower in the 1.5% kelp supplemented group than in the controls.ConclusionKelp supplementation improved kidney function of mink infected with AMDV with no effect on liver function, immune response to infection by AMDV or virus replication.