Diagnostic benefits of platelet-to-lymphocyte, neutrophil-to-lymphocyte, and albumin-to-globulin ratios in dogs with nasal cavity diseases

• DOI: 10.1186/s12917-024-03876-5
• Publication Date: 2024-02-03T07:02:28Z
• Authors: Sarah Rösch; Julia Woitas; Stephan Neumann; Michaele Alef; Ingmar Kiefer; Gerhard Oechtering
• Keywords: Complete blood count

Abstract Background A multimodal approach for diagnostic tests under anesthesia is required to diagnose nasal cavity pathology (NP) reliably in dogs. Blood test results may provide clues the suspected NP. Methods This prospective blinded study assessed 72 dogs with chronic discharge due NPs, and 10 healthy as control group (CG). NPs were diagnosed using whole-body computed tomography (CT), upper airway endoscopy, examination of mucosal swabs by bacterial fungal culture, histopathological mucosa biopsies. The exclusion criteria presence any additional diseases or corticosteroid pre-treatment. In consideration these criteria, 55 entered study. Dogs classified into benign (benign tumors, idiopathic rhinitis (IR), others) malignant (carcinomas sarcomas) NP groups. count blood chemistry performed. neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), albumin-to-globulin (AGR) calculated compared. Results 25 (13 12 carcinomas sarcomas, respectively) 30 (seven tumors,13 IR, included. general, there only slight abnormalities complete count. However, PLR was significantly higher (carcinoma sarcoma) than those CG. Compared CG, NLR increased all NP, AGR mild but lower, except sarcomas tumors. Conclusions disease alone, are usually no marked while mildly decreased can be observed almost an indicate a used screening tool pathology.