Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations
Genetics & Heredity
Inflammation
Research
Human Genome
Oncology and Carcinogenesis
610
Genetic Pleiotropy
Hispanic or Latino
Biological Sciences
Medical Biochemistry and Metabolomics
QH426-470
RC31-1245
3. Good health
Clinical Research
616
Genetics
2.1 Biological and endogenous factors
Medical biochemistry and metabolomics
Humans
Genetic pleiotropy
Obesity
Aetiology
Hispanic Americans
Internal medicine
Adiposity
DOI:
10.1186/s12920-022-01352-3
Publication Date:
2022-09-10T14:02:24Z
AUTHORS (25)
ABSTRACT
Abstract
Background
Concurrent variation in adiposity and inflammation suggests potential shared functional pathways and pleiotropic disease underpinning. Yet, exploration of pleiotropy in the context of adiposity-inflammation has been scarce, and none has included self-identified Hispanic/Latino populations. Given the high level of ancestral diversity in Hispanic American population, genetic studies may reveal variants that are infrequent/monomorphic in more homogeneous populations.
Methods
Using multi-trait Adaptive Sum of Powered Score (aSPU) method, we examined individual and shared genetic effects underlying inflammatory (CRP) and adiposity-related traits (Body Mass Index [BMI]), and central adiposity (Waist to Hip Ratio [WHR]) in HLA participating in the Population Architecture Using Genomics and Epidemiology (PAGE) cohort (N = 35,871) with replication of effects in the Cameron County Hispanic Cohort (CCHC) which consists of Mexican American individuals.
Results
Of the > 16 million SNPs tested, variants representing 7 independent loci were found to illustrate significant association with multiple traits. Two out of 7 variants were replicated at statistically significant level in multi-trait analyses in CCHC. The lead variant on APOE (rs439401) and rs11208712 were found to harbor multi-trait associations with adiposity and inflammation.
Conclusions
Results from this study demonstrate the importance of considering pleiotropy for improving our understanding of the etiology of the various metabolic pathways that regulate cardiovascular disease development.
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