Midregional Proatrial Natriuretic Peptide (MRproANP) is associated with vertebral fractures and low bone density in patients with chronic obstructive pulmonary disease (COPD)

• DOI: 10.1186/s12931-024-02902-2
• Publication Date: 2024-07-13T08:01:53Z
• Authors: Franziska C. Trud...; Rudolf A. Jörres; Peter Alter; Henrik Watz; Claus F. Vogelmeier; Hans-Ulrich Kauczor; Subasini Thangamani; Manuel Debic; Tobias Welte; Jürgen Behr; Kathrin Kahnert; Robert Bals; Christian Herr; Claus Peter Heußel; Jürgen Biederer; Oyunbileg von Sta...; Sebastian Fähndrich; Emiel F. M. Wouters; Benjamin Waschki; Klaus F. Rabe; Felix J. F. Herth; Viktoria Palm; ; Stefan Andreas; Kathrin Kanerth; Thomas Bahmer; Burkhard Bewig; Ralf Ewert; Beate Stubbe; Joachim H. Ficker; Christian Grohé; Matthias Held; Markus Henke; Anne-Marie Kirsten; Rembert Koczulla; Juliane Kronsbein; Cornelia Kropf-Sa...; Christian Herzmann; Michael Pfeifer; Winfried J. Rande...; Werner Seeger; Michael Studnicka; Christian Taube; Hartmut Timmermann; Bernd Schmeck; Hubert Wirtz
• Keywords: Male; OSTEOPOROSIS; Cohort Studies; Diseases of the respiratory system; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; 0302 clinical medicine; Bone Density; Humans; COHORT; Protein Precursors; PREDICTORS; POPULATION; Aged; RC705-779; Research; STANDARDIZATION; Middle Aged; SPIROMETRY; Spinal Fractures; Female; Atrial Natriuretic Factor; Biomarkers; Osteoporotic Fractures

Abstract Background Patients with COPD are often affected by loss of bone mineral density (BMD) and osteoporotic fractures. Natriuretic peptides (NP) known as cardiac markers, but have also been linked to fragility-associated fractures in the elderly. As their functions include regulation fluid balance, they might affect metabolism, particularly systemic disorders such COPD. Research question We investigated association between NP serum levels, vertebral BMD assessed chest computed tomography (CT) patients Methods Participants COSYCONET cohort CT scans were included. Mean on (BMD-CT) a risk factor for osteoporosis was at level TH12 (AI-Rad Companion), compression visually quantified two readers. Their relationship N-terminal pro-B-type natriuretic peptide (NT-proBNP), Mid-regional pro-atrial (MRproANP) Midregional pro-adrenomedullin (MRproADM) determined using group comparisons multivariable analyses. Results Among 418 participants (58% male, median age 64 years, FEV 1 59.6% predicted), found 76 (18.1%). Compared without fractures, these had elevated levels ( p ≤ 0.005) MRproANP MRproADM. Using optimal cut-off values multiple logistic regression analyses, ≥ 65 nmol/l (OR 2.34; = 0.011) 0.009) only significant predictors after adjustment sex, BMI, smoking status, % predicted, SGRQ Activity score, daily physical activity, oral corticosteroids, diagnosis disease, renal impairment. Correspondingly, < 0.001), 0.055), score 0.061) active 0.025) associated density. Interpretation marker our from cohort. Its reduced its modulating effects ion balance suggestive direct mineralization. Trial registration ClinicalTrials.gov NCT01245933, Date registration: 18 November 2010.