Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance

• DOI: 10.1186/s12933-015-0184-5
• Publication Date: 2015-02-09T11:28:20Z
• Authors: Aida Medina-Urrutia; Carlos Posadas-Ro...; Rosalinda Posadas...; Esteban Jorge-Gal...; Teresa Villarreal...; María del Carmen ...; Guillermo Cardoso...; Gilberto Vargas-A...; Margarita Torres-...; Juan Gabriel Juár...
• Keywords: Abdominal obesity; Angiology; Intra-Abdominal Fat

Experimental studies have shown that high free fatty acid (FFA) and low adiponectin (ADIPO) levels are involved in the mechanisms by which adiposity promotes insulin resistance (IR). However, no previous clinical simultaneously analysed relative contribution of FFA ADIPO on relation abdominal visceral fat (AVF) with resistance. To analyse (adiponectin < =p25th: 8.67 μg/mL women 5.30 men), FFAs (FFAs > =p75th: 0.745 mEq/L 0.60 men) to association AVF (AVF 127 cm2 women; 152.7 (HOMA-IR =75th: 3.58 3.12 non-diabetic subjects. A cross-sectional analysis was performed including 1217 control participants Genetics Atherosclerotic Disease study (GEA). Clinical, tomographic biochemical parameters were measured all participants. Logistic regression models used assess IR stratifying according gender, normal or serum levels. In comparison referent group, men unlike increased risk IR. Females ADIPO, had aprox 3 folds (OR [IC95%]: 3.7 [2.1-6.6], p 0.001, 3.4 [2.0-5.7], 0.001; respectively). The 7.6 [4.2-13.8], 0.001 when present. Irrespective AVF, effect higher than seen for FFA. Besides, our results suggest an additive prevalence. present provides novel important information about combined Furthermore, data AVF-IR is stronger observed FFA, suggesting could be as biomarker identify subjects at T2DM CAD.