Effects of exenatide on postprandial vascular endothelial dysfunction in type 2 diabetes mellitus

• DOI: 10.1186/s12933-015-0188-1
• Publication Date: 2015-02-17T07:43:32Z
• Authors: Keiichi Torimoto; Yosuke Okada; Hiroko Mori; Takashi Otsuka; Mayuko Kawaguchi; Megumi Matsuda; Fumi Kuno; Kei Sugai; Satomi Sonoda; Maiko Hajime; Kenichi Tanaka; Tadashi Arao; Yoshiya Tanaka
• Keywords: Endothelial Dysfunction; Reactive hyperemia

Basic studies have shown that glucagon-like peptide-1 (GLP-1) analogs exert a direct protective effect on the vascular endothelium in addition to their indirect effects postprandial glucose and lipid metabolism. GLP-1 are also reported inhibit endothelial dysfunction. This study examined whether analog exenatide inhibits dysfunction patients with type 2 diabetes mellitus (T2DM).Seventeen T2DM underwent meal tolerance test examine changes function metabolism, both without (baseline) after single subcutaneous injection of 10 μg exenatide. Vascular was determined using reactive hyperemia index (RHI) measured by peripheral arterial tonometry before 120 min loading test. The primary endpoint difference between baseline tests.The natural logarithmically-scaled RHI (L_RHI) significantly lower but not use resulted significant decrease triglycerides (TG) area under curve coefficient variation (CV). change L_RHI correlated CV HDL-cholesterol. Multivariate analysis identified triglyceride as only determinant L_RHI, contributing 41% observed change.Exenatide inhibited test, suggesting has multiphasic anti-atherogenic action involving metabolism.ClinicalTrials.gov: UMIN000015699.