Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients

• DOI: 10.1186/s12933-015-0214-3
• Publication Date: 2015-06-18T10:46:37Z
• Authors: Ming Zhang; Jaskanwal Deep Sara; Fei-long Wang; Li-Ping Liu; Li-Xiao Su; Jing Zhe; Xi Wu; Jing-hua Liu
• Keywords: Angiology; Intravascular Ultrasound

Although Bone morphogenetic protein-2 (BMP-2) is a known mediator of bone regeneration and vascular calcification, to date no study has investigated the relationship between BMP-2 type 2 diabetes mellitus (T2DM) its possible role in coronary artery disease (CAD). The purpose this evaluate with atherosclerosis calcification patients T2DM. 124 subjects were enrolled study: 29 T2DM CAD; 26 without 36 CAD T2DMand 34 or (control group). Severity lesions was assessed using angiography intravascular ultrasound (IVUS). Plasma levels quantified commercially available ELISA kit. Compared control group, mean plasma level significantly higher (20.1 ± 1.7 19.3 1.5 pg/ml, vs 17.2 3.3 P <0.001). In multivariable linear regression analysis, both positively associated (Estimate, 0.249; standard error (SE), 0.063; p <0.0001; Estimate, 0.400; SE, 0.06; <0.0001). also strongly correlated glycosylated hemoglobin A1c (HbA1c) (Spearman ρ = −0.31; 0.0005). SYNTAX score 0.46; 0.0002). Using results from IVUS, shown correlate plaque burden 0.38, 0.002) =0.44, 0.0003) negatively lumen volume =0.31, 0.01). Our demonstrates that had circulating than normal controls.