Impaired fasting glucose and left ventricular diastolic dysfunction in middle-age adults: a retrospective cross-sectional analysis of 2971 subjects

• DOI: 10.1186/s12933-015-0282-4
• Publication Date: 2015-09-14T21:19:30Z
• Authors: Assi Milwidsky; Elad Maor; Shaye Kivity; Anat Berkovitch; Sagit Ben Zekry; Alexander Tenenbaum; Enrique Z. Fisman; Aharon Erez; Shlomo Segev; Yechezkel Sidi; Ilan Goldenberg; Rafael Kuperstein
• Keywords: Impaired fasting glucose

Left ventricular (LV) diastolic dysfunction (LVDD) is a well-established and early echocardiographic characteristic of diabetic cardiomyopathy. However, there are limited data on the association between impaired fasting glucose (IFG) LVDD.To determine whether IFG associated with LVDD among middle age adults.Amongst 3781 subjects screened in an annual health survey program referred for echocardiogram, 2971 individuals without LV systolic or valvular heart disease were selected. Mean study population was 59 ± 12 years 75% men. The categorized into three groups: euglycemia (N = 2025), 534) diabetes mellitus (DM; N 412). Doppler echocardiography readers blinded to glycemic state. Subjects relaxation, pseudo-normal restrictive filling patterns defined as having LVDD.LVDD diagnosed 574 (19 %) it more prevalent patients DM than euglycemic (27, 30 15%, respectively; p < 0.001). Patients had lower ratios (E) late (A) trans-mitral flow (0.9 0.3 0.9 vs. 1.1 0.4, respectively, hypertrophy (LVH) also (11 18%, 9%; Multivariate binary logistic regression model adjusted age, gender, obesity, LVH, renal function, total, high low density lipoprotein cholesterol, triglycerides, ischemic disease, hypertension ejection fraction showed that 43% likely have compared (95% confidence interval 1.12-1.83, 0.004).IFG independently significant increase likelihood presence aged adults.