Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis

• DOI: 10.1186/s12933-015-0301-5
• Publication Date: 2015-10-13T06:04:44Z
• Authors: Federico Biscetti; Giuseppe Straface; Carlo Filippo Por...; Giovanni Bertoletti; Claudio Vincenzoni; Francesco Snider; Egidio Stigliano; Vincenzo Arena; Flavia Angelini; Giovanni Pecorini; Antonio Bianchi; Raffaele Landolfi; Andrea Flex
• Keywords: Angiology; Endarterectomy

The object of this study was to investigate the potential role FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. In retrospective observational study, we analyzed serum level 361 stenosis undergoing endarterectomy and 598 controls without atherosclerosis. We found that median levels significantly higher than [67.7 (59.5–77.8) pg/mL 43.89 (37.5–50.4), P < 0.001] independently associated unstable [OR, 5,71 (95 % CI, 2.09–15.29]. have found, for first time, could be