Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes

• DOI: 10.1186/s12933-016-0369-6
• Publication Date: 2016-03-24T04:41:33Z
• Authors: Andrew O. Odegaard; David R. Jacobs; Otto A. Sanchez; David C. Goff; Alexander P. Reiner; Myron D. Gross
• Keywords: Endothelial Dysfunction; Quartile

Oxidative stress, inflammation and endothelial dysfunction are interrelated factors in the etiology of cardiovascular disease, but their linkage to type 2 diabetes is less clear. We examined association these biomarkers with incident (T2D). Analysis 2339 participants community-based coronary artery risk development young adults (CARDIA) study. Participants (age 40.1 ± 3.6 years, 44 % Black, 58 women) were free diabetes, followed 10 years. Cox regression was used estimate hazard ratios (HRs) for T2D adjusting other under study, demographic lifestyle measures, dietary biomarkers, BMI (kg/m2) metabolic syndrome components. F2-isoprostanes oxidized LDL (oxidative stress) positively associated T2D, associations attenuated by adjustment BMI. C-reactive protein even full adjustment: HR (95 CI) = 2.21 (1.26–3.88) quartile 4 (Q4) v. 1 (Q1). The ICAM-1 E-selectin Q4 Q1 1.64 (0.96–2.81) 1.68 (1.04–2.71) respectively, adjustment. Including two markers a common score incorporating clinical measures improved prediction probability T2D: relative average person classified up compared down: 1.09, (1.06–1.13), P < 0.0001. Biomarkers T2D. add beyond score.