Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study

• DOI: 10.1186/s12933-017-0539-1
• Publication Date: 2017-04-25T22:32:53Z
• Authors: S. A. Peeters; L. Engelen; J. Buijs; A. Jorsal; H.-H. Parving; L. Tarnow; P. Rossing; C. G. Schalkwijk; C. D. A. Stehouwer
• Keywords: Angiology

Altered regulation of extracellular matrix remodeling by metalloproteinases (MMPs) and tissue inhibitor metalloproteinase (TIMP) may contribute to vascular complications in type 1 diabetes. We investigated associations between plasma MMP-1, -2, -3, -9, -10 TIMP-1, cardiovascular events all-cause mortality diabetic patients.We prospectively followed 337 patients [mean age 41.4 years (9.6), 39% female], 170 with 167 without nephropathy, median follow-up 12.3 years. Survival analyses were applied investigate differences -10, TIMP-1-levels a event those who died vs survivors. All adjusted for age, sex, duration diabetes, HbA1c, nephropathy other conventional risk factors.After adjustment potential confounders, higher MMP-2 levels significantly associated incidence [HR 1.49 (95% CI 1.11; 1.99)], MMP-1 [1.38 (1.07; 1.78)], [1.60 (1.19; 2.15)] MMP-3 [1.39 (1.05; 1.85)] mortality. independent low-grade inflammation endothelial dysfunction as estimated markers. Associations attenuated after further eGFR changes eGFR.Higher are CVD -2 -3 In addition, CVD, while both MMPs decline, indicating possible mediating role eGFR.