The role of physical activity in the development of first cardiovascular disease event: a tree-structured survival analysis of the Danish ADDITION-PRO cohort

• DOI: 10.1186/s12933-018-0769-x
• Publication Date: 2018-09-12T05:01:07Z
• Authors: Hanan Amadid; Nanna B. Johansen; Anne-Louise Bjerr...; Søren Brage; Kristine Færch; Torsten Lauritzen; Daniel R. Witte; Annelli Sandbæk; Marit E. Jørgensen; Dorte Vistisen
• Keywords: Metabolic equivalent; Angiology

Ambiguity exists in relation to the role of physical activity (PA) for cardiovascular disease (CVD) risk reduction. We examined interplay between PA dimensions and more conventional CVD factors assess which were associated with first event whether subgroup differences exist. A total 1449 individuals [median age 65.8 (IQR: 61.2, 70.7) years] low high type 2 diabetes free from Danish ADDITION-PRO study included survival analysis. was measured by individually calibrated heart rate movement sensing 7 consecutive days. The associations different (PA energy expenditure, time spent light-, moderate- vigorous intensity PA), sedentary other tree-structured Baseline information linked data on (ischemic disease, ischemic stroke, failure, atrial flutter/fibrillation atherosclerotic disease) mortality obtained registers. During a median follow-up 5.5 5.1–6.1) years, 201 (13.9%) developed CVD. Overall incidence 2.6/100 person-years. expenditure above 43 kJ/kg/day lower rates events among participants ≤ 70 years HbA1c 5.7% (39 mmol/mol), systolic blood pressure 156 mmHg albumin creatinine ratio (incidence 0.0–0.8/100 person-years). Any resulting increased may over be best prevention strategy uphold reduced