Influence of preprocedural glycemic control on clinical outcomes of endovascular therapy in diabetic patients with lower extremity artery disease: an analysis from a Korean multicenter retrospective registry cohort

• DOI: 10.1186/s12933-020-01072-x
• Publication Date: 2020-06-22T16:03:52Z
• Authors: Jung-Joon Cha; Hyoeun Kim; Young-Guk Ko; Donghoon Choi; Jae-Hwan Lee; Chang-Hwan Yoon; In-Ho Chae; Cheol Woong Yu; Seung Whan Lee; Sang-Rok Lee; Seung Hyuk Choi; Yoon Seok Koh; Pil-Ki Min; ; Woong Chol Kang; Sung-Ho Her; Yoon Seok Koh; Byung-Hee Hwang; Byung-Hee Hwang; Ae-Young Her; Weon Kim; Cheol Woong Yu; Sang Cheol Jo; Sang Cheol Jo; Sanghoon Shin; Yun Hyeong Cho; Woo-Young Chung; In-Ho Chae; Chang-Hwan Yoon; Jung Kyu Han; Seung Whan Lee; Seung Hyuk Choi; Young Jin Choi; Su Hyun Kim; Sang Ho Park; Pil-Ki Min; Donghoon Choi; Young-Guk Ko; Young Jin Yoon; Jung-Hee Lee; Yu Jeong Choi; Sung Kee Ryu; Ju Han Kim; Sang-Rok Lee; Hoyoun Won; Ju Yeol Baek; Jae-Hwan Lee; Jang-Hwan Bae; Hyun-Sook Kim
• Keywords: Critical limb ischemia

Abstract Background The influence of intensive glucose control in diabetic patients on the macrovascular outcomes is controversial. Thus, this study aimed to elucidate effect preprocedural hemoglobin A1c (HbA1c) clinical after endovascular therapy for lower extremity artery disease (LEAD) patients. Methods Diabetic were enrolled from retrospective cohorts a Korean multicenter registry and divided according HbA1c level during index admission into optimal (< 7.0%) or suboptimal (≥ glycemic groups. primary endpoints major adverse limb events (MALE, composite amputation, minor reintervention). Results Of 1103 (897 men, mean age 68.2 ± 8.9 years), 432 (39.2%) classified group 671 (60.8%) group. In-hospital immediate procedural complications not different between two showed trend towards higher incidence MALE than (log-rank p = 0.072). Although no significant differences found groups terms overall survival risk reintervention was significantly 0.048). In multivariate Cox regression model, one independent predictors reintervention. When our data analyzed initial presentation, increased compared with only intermittent claudication. Conclusion undergoing LEAD, associated an events, especially Further prospective research will be required validate role more reduction LEAD.