Association between cholesterol efflux capacity and peripheral artery disease in coronary heart disease patients with and without type 2 diabetes: from the CORDIOPREV study

• DOI: 10.1186/s12933-021-01260-3
• Publication Date: 2021-03-25T14:03:04Z
• Authors: Elena M. Yubero-S...; Juan F. Alcalá-Diaz; Francisco M. Guti...; Antonio P. Arenas...; Patricia J. Peña-...; Ruth Blanco-Rojo; Javier Martinez-B...; Jose D. Torres-Peña; Pablo Perez-Martinez; Jose M. Ordovas; Javier Delgado-Lista; Diego Gómez-Coronado; Jose Lopez-Miranda
• Keywords: Angiology

Abstract Background Peripheral artery disease (PAD) is recognized as a significant predictor of mortality and adverse cardiovascular outcomes in patients with coronary heart (CHD). In fact, coexisting PAD CHD strongly associated greater event recurrence compared either one them alone. High-density lipoprotein (HDL)-mediated cholesterol efflux capacity (CEC) found to be inversely an increased risk incident CHD. However, this association not established the context secondary prevention. sense, our main aim was evaluate between CEC whether concurrent presence T2DM influences association. Methods (n = 1002) from CORDIOPREV study were classified according or absence (ankle-brachial index, ABI ≤ 0.9 > < 1.4, respectively) status. quantified by incubation cholesterol-loaded THP-1 cells participants' apoB-depleted plasma performed. Results The determined low non-T2DM newly-diagnosed patients. Coexisting provided additive effect providing impaired PAD. patients, did determine differences CEC, those without PAD, which may restored glucose-lowering treatment. Conclusions Our findings suggest inverse relationship These results support importance identifying underlying mechanisms prevention, that provide potential therapeutic targets, case establishing strategies prevent reduce high events these Trial registration https://clinicaltrials.gov/ct2/show/NCT00924937 . Unique Identifier: NCT00924937