TyG index is positively associated with risk of CHD and coronary atherosclerosis severity among NAFLD patients

• DOI: 10.1186/s12933-022-01548-y
• Publication Date: 2022-07-01T15:09:11Z
• Authors: Jianqi Zhao; Hongxuan Fan; Ting Wang; Bing Yu; Shaobin Mao; Xun Wang; Wenjing Zhang; Leigang Wang; Yao Zhang; Zhaoyu Ren; Bin Liang
• Keywords: Angiology

Insulin resistance (IR), endothelial dysfunction, inflammation, glucose and lipid metabolism disorders, thrombosis are believed involved in coronary heart disease (CHD) non-alcoholic fatty liver (NAFLD). Triglyceride-glucose (TyG) index, a new IR indicator, is correlated with NAFLD occurrence severity, but its relationship CHD risk remains unclear. This study investigated the correlation between TyG index among patients.This cross-sectional included 424 patients chest pain Department of Cardiology, The Second Hospital Shanxi Medical University, from January 2021 to December 2021. was calculated angiography performed. All individuals were divided into + groups then by level. t-test, Mann-Whitney U-test, or one-way analysis variance compared differences continuous variables, while chi-square test Fisher's exact categorical variables. Logistic regression determined independent protective hazardous factors CHD. receiver operating characteristic curve evaluated ability different rule-in thresholds predict Gensini score using linear multiple regression.CHD detected 255 patients. Compared group, multivariate logistic showed that factor for after adjustment age, sex, hypertension, diabetes mellitus highest odds ratio (OR, 2.519; 95% CI, 1.559-4.069; P < 0.001). TG, low-density lipoprotein cholesterol, FBG TYG-body mass also High-density cholesterol level events NAFLD. In an in-depth analysis, each 1-unit increase associated 2.06-fold increased 2.06; 1.16-3.65; = 0.013). multifactor 0.1-unit NAFLD-CHD group 2.44 (β 2.44; 0.97-3.91; 0.002).The positively reflected atherosclerosis severity.