Prognostic value of coronary microvascular dysfunction assessed by coronary angiography-derived index of microcirculatory resistance in diabetic patients with chronic coronary syndrome

• DOI: 10.1186/s12933-022-01653-y
• Publication Date: 2022-10-29T17:03:19Z
• Authors: Wen Zhang; Shekhar Singh; Lu Liu; Abdul-Quddus Moha...; Guoqing Yin; Siling Xu; Xian Lv; Tingting Shi; Cailin Feng; Rong Jiang; Ayman A. Mohammed; Redhwan M. Mareai; Yawei Xu; Xuejing Yu; Fuad A. Abdu; Wenliang Che
• Keywords: Mace; Angiology; Clinical endpoint

Abstract Background Coronary microvascular dysfunction (CMD) is common and associated with unfavorable cardiovascular events in patients diabetes mellitus (DM). angiography-derived index of microcirculatory resistance (caIMR) a recently developed wire- hyperemic agent-free method to assess CMD. We aimed investigate the prognostic impact CMD assessed by caIMR on clinical outcomes DM chronic coronary syndrome (CCS). Methods CCS who underwent angiography between June 2015 May 2018 were included. function was measured caIMR, defined as ≥ 25U. The primary endpoint major adverse cardiac (MACE). Kaplan-Meier analysis Cox proportional hazards models used relationship risk MACE. Results Of 290 patients, 102 had DM. Compared non-diabetic (caIMR 25U) higher among (57.8% vs. 38.3%; p = 0.001). During mean 35 months follow-up, 40 MACE occurred. Patients 25 rate than < (20.6% 8.2%, 0.002). these, those (33.9% 14.0%; 0.022). In multivariable analysis, independently but not non-DM (HR, 2.760; 95% CI, 1.066–7.146; P 0.036). Conclusion an independent predictor diabetic CCS. This finding potentially enables triage higher-risk more intensive therapy.