Impaired insulin-stimulated myocardial glucose metabolic rate is associated with reduced estimated myocardial energetic efficiency in subjects with different degrees of glucose tolerance

• DOI: 10.1186/s12933-022-01733-z
• Publication Date: 2023-01-09T11:03:44Z
• Authors: Elena Succurro; Francesco Cicone; Annalisa Papa; Sofia Miceli; Patrizia Vizza; Teresa Vanessa Fi...; Maria Perticone; Angela Sciacqua; Pietro Hiram Guzzi; Pierangelo Veltri; Giuseppe Lucio Ca...; Francesco Andreozzi; Giorgio Sesti
• Keywords: Carbohydrate Metabolism; Angiology; Glucose clamp technique

Alterations in myocardial mechano-energetic efficiency (MEEi), which represents the capability of left ventricles to convert chemical energy obtained by oxidative metabolism into mechanical work, have been associated with cardiovascular disease. Although whole-body insulin resistance has related impaired MEEi, it is unknown relationship between cardiac and MEEi. Aim this study was evaluate insulin-stimulated glucose metabolic rate (MrGlu) MEEi subjects having different degrees tolerance.We evaluated MrGlu using dynamic positron emission tomography (PET) 18F-Fluorodeoxyglucose (18F-FDG) combined euglycemic-hyperinsulinemic clamp, 57 individuals without history coronary heart disease tolerance. The were stratified tertiles according their values.After adjusting for age, gender BMI, I tertile showed a decrease (0.31 ± 0.05 vs 0.42 0.14 ml/s*g, P = 0.02), an increase oxygen consumption (MVO2) (10,153 1375 7816 1229 mmHg*bpm, < 0.0001) as compared III tertile. Univariate correlations that positively correlated disposal, negatively waist circumference, fasting plasma glucose, HbA1c MVO2. In multivariate regression analysis running model including several CV risk factors, only variable remained significantly (β 0.346; 0.01).These data suggest impairment independent contributor depressed CHD.