Diabetes and aortic dissection: unraveling the role of 3-hydroxybutyrate through mendelian randomization

• DOI: 10.1186/s12933-024-02266-3
• Publication Date: 2024-05-07T15:02:18Z
• Authors: Shi Qiu; Zhen Liu; Wei-Dong Jiang; Jin-Hui Sun; Zeng-Qiang Liu; Xiao-Di Sun; Chun-Ting Wang; Wen Liu
• Keywords: Mendelian Randomization; Angiology

In observational and experimental studies, diabetes has been reported as a protective factor for aortic dissection. 3-Hydroxybutyrate, key constituent of ketone bodies, found to favor improvements in cardiovascular disease. However, whether the effect on dissection is mediated by 3-hydroxybutyrate unclear. We aimed investigate causal effects risk mediating role them through two-step Mendelian randomization.