Joint assessment of abdominal obesity and non-traditional lipid parameters for primary prevention of cardiometabolic multimorbidity: insights from the China health and retirement longitudinal study 2011–2018

• DOI: 10.1186/s12933-025-02667-y
• Publication Date: 2025-03-08T17:00:26Z
• Authors: Hurong Lai; Yansong Tu; Caifeng Liao; Shan Zhang; Ling He; Jian Li
• Keywords: Abdominal obesity; Angiology; Cardiovascular Health; Primary Prevention

Obesity and abnormal lipid metabolism increase the risk of various cardiometabolic diseases, including diabetes, heart disease, stroke. However, impact abdominal obesity (AO) non-traditional parameters on multimorbidity (CMM) remains unclear. This study aims to investigate separate combined effects AO incidence CMM. enrolled 7,597 eligible participants from China health retirement longitudinal (CHARLS). Cox proportional hazards models were used perform adjusted regression analyses mediation analyses, with Kaplan-Meier analysis for cumulative hazards. Restricted cubic splines utilized evaluate nonlinear relationship between CMM among AO. Subgroup conducted stratification by age, gender, BMI, smoking status, drinking hypertension interaction across different populations. Additionally, sensitivity further performed subgroups During 7-year follow-up period, a total 699 (9.20%) newly diagnosed curves revealed that subgroup both high levels had highest hazard developing In fully model, exhibited confirmed robustness these findings, showing consistent results demographic groups under analytical conditions. Furthermore, was found significantly mediated associations The associated Notably, may induce partially mediating serum lipids in human metabolism. findings highlighted importance joint evaluation primary prevention