Unexpected high circulation of Plasmodium vivax in asymptomatic children from Kédougou, southeastern Senegal

• DOI: 10.1186/s12936-017-2146-8
• Publication Date: 2017-12-29T01:09:42Z
• Authors: Makhtar Niang; Fode Diop; Oulimata Niang; Bacary D. Sadio; Abdourahmane Sow; Ousmane Faye; Mawlouth Diallo; Amadou A. Sall; Ronald Perraut; Aissatou Toure-Balde
• Keywords: Parasitology; Tropical Medicine

Malaria in Senegal is due essentially to infections by Plasmodium falciparum and, a lesser extent malariae and ovale. By the use of molecular methods, detection vivax has been recently reported region Kedougou, raising question appraisal its potential prevalence this setting. A retrospective serological study was carried out using 188 samples taken from 2010 2011 longitudinal school survey during which 48 asymptomatic children (9–11 years) were recruited. Four collections collected two successive dry rainy seasons analysed for antibody responses P. falciparum. Recombinant MSP1 antigens total schizont lysate African 07/03 strain (adapted culture) used ELISA. Nested PCR amplification vivax. surprising high IgG against evidenced with 53% positive 58% individuals that found antigen. There 77% responders outlined 63% samples. Prevalence did not differ as function seasons. Levels antibodies fluctuated significant increasing between season (P < 0.05), contrary reciprocal relationship 10−3) different antigens, but weak coefficient correlation (Rho around 0.3) underlining variable profile at individual level. Clear signature msp1 PCR. This cross-sectional highlights unexpected circulation endemic area. Sero-immunology methods are powerful additive tools identify sites where relevant control measures have be settled monitored.