Postprandial triglyceride response in normolipidemic, hyperlipidemic and obese subjects – the influence of polydextrose, a non-digestible carbohydrate

• DOI: 10.1186/s12937-015-0009-0
• Publication Date: 2015-03-07T07:00:57Z
• Authors: Kirsti Tiihonen; Nina Rautonen; Esa Alhoniemi; Markku Ahotupa; Julian Stowell; Tommi Vasankari
• Keywords: Polydextrose; Clinical nutrition; Crossover study

Three independent trials were conducted to evaluate postprandial triglyceride (TG) responses in subjects with different lipid metabolism. The effect of polydextrose (PDX), a soluble non-digestible carbohydrate, on response was also studied using practically relevant, high fat meal interventions.A total 19 normolipidemic (average BMI 24.1 kg/m(2)), 21 overweight/hyperlipidemic 29.6 kg/m(2)) and 18 obese/non-diabetic 33.6 included the study. On two separate occasions all ate high-fat meals (4293 kJ, 36% from fat), one PDX (either 12.5 g or 15 g) without during placebo-controlled, double-blind, crossover randomized trials. To obtain measurements venous blood samples taken before consumption test five times afterwards, up 6 h post-test meal. modeled mixed-effects linear model.The key variables that explain variation subject groups were: baseline concentration, time point, vs. placebo treatment (p < 0.05). maximum TG concentration more pronounced hyperlipidemic group compared 0.001) obese 0.01). analysis showed irrespective study population supplementation factors significantly reducing 0.05).Subjects elevated fasting levels display exaggerated prolonged responses. PDX, may offer dietary concept for after containing fat.