In-utero exposure to phenols and phthalates and the intelligence quotient of boys at 5 years

• DOI: 10.1186/s12940-018-0359-0
• Publication Date: 2018-02-20T02:20:33Z
• Authors: Dorothy Nakiwala; Hugo Peyre; Barbara Heude; Jonathan Y. Bernard; Rémi Béranger; Rémy Slama; Claire Philippat
• Keywords: Male; [SDV]Life Sciences [q-bio]; Intelligence; Phthalic Acids; 610; Parabens; 01 natural sciences; Bisphenol A; Phenols; Pregnancy; Prenatal exposure; Humans; Prospective Studies; Endocrine disruptors; 0105 earth and related environmental sciences; Intelligence Tests; Research; Industrial medicine. Industrial hygiene; Triclosan; 6. Clean water; [SDV] Life Sciences [q-bio]; RC963-969; [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie; Maternal Exposure; Child, Preschool; Phthalate; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Environmental Pollutants; Female; Cognitive function; Intelligence quotient; France; Public aspects of medicine; RA1-1270

There are concerns that developmental exposure to endocrine disrupting chemicals such as phenolic compounds and phthalates could affect child cognitive function. Epidemiological studies tackling this question have mainly focused on phthalate metabolites bisphenol A, but not the other compounds. Our study aimed assess relationship between in-utero phthalates, A (parabens, triclosan, dichlorophenols benzophenone-3) Intelligence Quotient (IQ) of boys at 5-6 years.In 452 mother-son dyads from French EDEN cohort, we measured 11 9 (4 parabens, benzophenone-3, 2 triclosan) in spot urine samples collected 22 29 gestational weeks. Verbal performance IQ children were assessed years by a psychologist using Wechsler Preschool Primary Scale (WPPSI). We used adjusted Structural Equation Models (SEM) combined with Benjamini Hochberg false discovery rate correction associations maternal phenol metabolite concentrations considered simultaneously boys' IQ.No or concentration was negatively associated verbal (uncorrected p-values ≥0.09). Mono(3-carboxypropyl) tended be increased (β = 0.136, 95% confidence interval, 0.01; 0.27). This association disappeared after for multiple comparison (corrected p-value, 0.71).Our results did provide evidence an inverse phenols among boys. Since may sex-specific effects, these null findings cannot generalized girls. Limitations included use single sample exposures lack consideration postnatal exposures.