Intake of medium-chain fatty acids induces myocardial oxidative stress and atrophy

• DOI: 10.1186/s12944-018-0908-0
• Publication Date: 2018-11-17T04:44:00Z
• Authors: Yoshihiro Miyagawa; Takuya Mori; Kei Goto; Isao Kawahara; Rina Fujiwara-Tani; Shingo Kishi; Takamitsu Sasaki; Kiyomu Fujii; Hitoshi Ohmori; Hiroki Kuniyasu
• Keywords: Male; 2. Zero hunger; Mice, Inbred BALB C; 0303 health sciences; Cachexia; RC620-627; Research; Myocardium; Body Weight; Fatty Acids; Medium-chain fatty acids; Lauric Acids; Heart; Quadriceps Muscle; 3. Good health; Mice; Muscular Atrophy; Oxidative Stress; 03 medical and health sciences; Oxidative stress; Cardiac dysfunction; Animals; Nutritional diseases. Deficiency diseases

Oral intake of medium-chain fatty acids (MCFAs) reportedly suppresses the accumulation visceral fat and has antitumor effects in tumor-bearing animals. MCFAs penetrate mitochondrial membrane a carnitine shuttle-independent manner are metabolized more quickly than long-chain acids. Based on these characteristics, may have pronounced mitochondria-rich tissues, such as myocardium. We examined effect oral heart.We fed BALB/c mice with control diet supplemented 0%, 2%, 5%, or 10% lauric acid (LAA; 12-carbon saturated MCFA). After euthanasia, hearts, both sides quadriceps femoris muscle (QFM) epididymal pad (EFP) were excised weighed. Then myocardial tissue morphology, oxidative stress accumulation, volume observed by histological analysis. The expression levels myosin light chain 1 measured ELISA.There no differences among groups food calorie intake, but LAA increased dietary proportion. 10%-LAA-fed experienced significant weight loss became moribund day 6. body, cardiac EFP weights 5% lower those group. And group showed decrease QFM weights. Protein analysis hearts revealed higher Histological examination atrophy Fewer mitochondria intake.Excessive consumption damage myocardium might result from cellular atrophy.