A specific combined long-chain polyunsaturated fatty acid supplementation reverses fatty acid profile alterations in a mouse model of chronic asthma

• DOI: 10.1186/s12944-018-0947-6
• Publication Date: 2019-01-18T12:02:56Z
• Authors: D. Fussbroich; K. Zimmermann; A. Göpel; O. Eickmeier; J. Trischler; S. Zielen; R. Schubert; C. Beermann
• Keywords: Docosapentaenoic acid

The immune-modulating potential of long-chain polyunsaturated fatty acids (LCPUFAs) based on their conversion into lipid mediators in inflammatory situations has been proven by several studies. Respecting the immune-modulative role bronchoconstriction, airway inflammation and resolution processes, LCPUFAs play an important asthma. To design a disease-specific most beneficial LCPUFA supplementation strategy, it is essential to understand how asthma alters profiles. Therefore, this study characterizes alterations profiles induced allergic In addition, explores whether simple eicosapentaenoic acid (EPA) alone or specific combined could restore imbalanced Mice were sensitized with daily dose 40 μg house dust mite (HDM)-extract recall model fed either normal diet, EPA (sc)-LCPUFA containing EPA, docosahexaenoic (DHA), γ -linolenic (GLA) stearidonic (SDA) for 24 days. After HDM, mice sacrificed blood lung tissue collected. Fatty determined plasma, cells asthmatic capillary gas-chromatography. mice, arachidonic (AA, p < 0.001) DHA (p 0.01) increased while dihomo-γ-linolenic (DGLA, 0.05) was decreased. only docosapentaenoic (DPA, 0.001), but neither DGLA nor mice. contrast, dietary n-3 n-6 decrease AA increase DPA reverse lack 0.05). summary, tissue. contrast supplementation, distinct combination restored completely. Subsequently, sc-LCPUFA likely be highly supportive limiting resolving process