The association of lipid ratios with hyperuricemia in a rural Chinese hypertensive population

• DOI: 10.1186/s12944-021-01556-z
• Publication Date: 2021-09-29T15:03:33Z
• Authors: Yu Yu; Tian Lan; Dandan Wang; Wangsheng Fang; Yu Tao; Minghui Li; Xiao Huang; Wei Zhou; Tao Wang; Lingjuan Zhu; Huihui Bao; Xiaoshu Cheng
• Keywords: Male; Rural Population; Lipid ratios; China; RC620-627; Hyperuricemia; 03 medical and health sciences; 0302 clinical medicine; High-density lipoprotein cholesterol; Risk Factors; Odds Ratio; Humans; Registries; Nutritional diseases. Deficiency diseases; Triglycerides; Aged; Research; Cholesterol, HDL; Reproducibility of Results; Cholesterol, LDL; Middle Aged; Lipids; 3. Good health; Cross-Sectional Studies; Hypertension; Rural China; Regression Analysis; Female

Abstract Background Current studies support lipid ratios [the total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio; the triglyceride (TG)/HDL-C ratio; the low-density lipoprotein cholesterol (LDL -C)/HDL-C ratio; and non-HDL-C] as reliable indicators of cardiovascular disease, stroke, and diabetes. However, whether lipid ratios could serve as markers for hyperuricemia (HUA) remains unclear due to limited research. This study aimed to explore the association between lipid ratios and HUA in hypertensive patients.

Methods The data from 14,227 Chinese hypertensive individuals in the study were analyzed. Multiple logistic regression analysis and smooth curve fitting models examined the relationship between lipid ratios and HUA.

Results The results showed positive associations between the lipid ratios and HUA (all P < 0.001). Furthermore, lipid ratios were converted from continuous variables to tertiles. Compared to the lowest tertile, the fully adjusted ORs (95 % CI) of the TC/HDL-C ratio, the TG/HDL-C ratio, the LDL-C/HDL-C ratio, and non-HDL-C in the highest tertile were 1.79 (1.62, 1.99), 2.09 (1.88, 2.32), 1.67 (1.51, 1.86), and 1.93 (1.74, 2.13), respectively (all P < 0.001).

Conclusions The study suggested that high lipid ratios (TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio, and non-HDL-C) are associated with HUA in a Chinese hypertensive population. This study’s findings further expand the scope of the application of lipid ratios. These novel and essential results suggest that lipid ratio profiles might be potential and valuable markers for HUA.

Trial registration No. ChiCTR1800017274. Registered July 20, 2018.