PEGylated crushed gold shell-radiolabeled core nanoballs for in vivo tumor imaging with dual positron emission tomography and Cerenkov luminescent imaging

• DOI: 10.1186/s12951-018-0366-x
• Publication Date: 2018-04-18T12:03:19Z
• Authors: Sang Bong Lee; Dinesh Kumar; Yinghua Li; In-Kyu Lee; Sung Jin Cho; Sang Kyoon Kim; Sang-Woo Lee; Shin Young Jeong; Jaetae Lee; Yong Hyun Jeon
• Keywords: Biodistribution; Molecular Imaging

Radioactive isotope-labeled gold nanomaterials have potential biomedical applications. Here, we report the synthesis and characterization of PEGylated crushed shell-radioactive iodide-124-labeled core nanoballs (PEG-124I-Au@AuCBs) for in vivo tumor imaging applications through combined positron emission tomography Cerenkov luminescent (PET/CLI). PEG-124I-Au@AuCBs showed high stability sensitivity various pH solutions, serum, conditions were not toxic to tested cells. Combined PET/CLI clearly revealed lesions at 1 h after injection particles, both signals remained visible 24 h, consistent with biodistribution results. Taken together, data provided strong evidence application as promising agents nuclear medicine biological systems, particularly cancer diagnosis.