Biomimetic black phosphorus quantum dots-based photothermal therapy combined with anti-PD-L1 treatment inhibits recurrence and metastasis in triple-negative breast cancer

• DOI: 10.1186/s12951-021-00932-2
• Publication Date: 2021-06-13T21:02:27Z
• Authors: Peiqi Zhao; Yuanlin Xu; Wei Ji; Shiyong Zhou; Lanfang Li; Lihua Qiu; Zhengzi Qian; Xianhuo Wang; Huilai Zhang
• Keywords: Triple-negative breast cancer; Targeted Therapy; Cancer Immunotherapy; Black Phosphorus

Abstract Background Triple-negative breast cancer (TNBC) is a highly aggressive malignant disease with high rate of recurrence and metastasis, few effective treatment options poor prognosis. Here, we designed constructed combined photothermal immunotherapy strategy based on cell membrane-coated biomimetic black phosphorus quantum dots (BBPQDs) for tumor-targeted therapy anti-PD-L1 mediated immunotherapy. Results BBPQDs have good conversion efficiency can efficiently target tumor cells through homologous targeting homing. Under near infrared irradiation, found that kill tumors directly effects induce dendritic maturation. In vivo studies confirmed the displays stronger antitumor activity than monotherapy. addition, BBPQDs-mediated in combination inhibit metastasis by reprograming immunosuppressive microenvironment into an immune-active microenvironment, promoting local systemic immune response. We further produce memory effect against rechallenge. Conclusions This study provides novel therapeutic inhibiting TNBC, broad application prospects.