Improving the ameliorative effects of berberine and curcumin combination via dextran-coated bilosomes on non-alcohol fatty liver disease in mice

• DOI: 10.1186/s12951-021-00979-1
• Publication Date: 2021-08-04T07:02:52Z
• Authors: Yi Chen; Zhaohui Jiang; Jinzhuan Xu; Jiyuan Zhang; Runbin Sun; Jia Zhou; Yuan Lu; Zipeng Gong; Jing Huang; Xiangchun Shen; Qianming Du; Jianqing Peng
• Keywords: Biodistribution

The combination of berberine (BER) and curcumin (CUR) has been verified with ameliorative effects on non-alcohol fatty liver disease (NAFLD). However, discrepant bioavailability biodistribution BER CUR remained an obstacle to achieve synergistic effects. Multilayer nanovesicles have great potential for the protection oral delivery drug combinations. Therein lies bile salts inserted liposomes, named as bilosomes, that possesses long residence time in gastrointestinal tract (GIT) permeability across small intestine. Diethylaminoethyl dextran (DEAE-DEX) is generally used outside layer increase mucinous stability promote absorption. Herein, we developed a DEAE-DEX-coated bilosome encapsulated (DEAE-DEX@LSDBC) treatment NAFLD.DEAE-DEX@LSDBC 150 nm size exhibited enhanced permeation mucus Caco-2 monolayer. In vivo pharmacokinetics study demonstrated DEAE-DEX@LSDBC profoundly prolonged circulation improved absorption both CUR. Intriguingly, synchronized highest at was achieved by DEAE-DEX@LSDBC, which contributed optimal NAFLD. It further be mainly mediated anti-oxidation anti-inflammation related pathways CONCLUSION: DEAE-DEX coated displayed promoted absorption, CUR, leading NAFLD mice, provided promising strategy administration