Cyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice

• DOI: 10.1186/s12951-022-01474-x
• Publication Date: 2022-06-03T10:03:45Z
• Authors: Daozhou Liu; Qifeng Ji; Ying Cheng; Miao Liu; Bangle Zhang; Qibing Mei; Menglei Huan; Siyuan Zhou
• Keywords: MPTP; Stroke

Ischemic stroke is one of the main causes death and disability in world. The treatment for ischemic to restore blood perfusion as soon possible. However, when brain tissue re-perfused by blood, mitochondrial permeability transition pore (mPTP) neuron microglia excessively opened, resulting apoptosis nerve inflammation. This aggravates injury. Cyclosporine A (CsA) inhibits over-opening mPTP, subsequently reducing release ROS cerebral ischemia/reperfusion injured microglia. CsA insoluble water present high concentrations lymphatic tissue. Herein, infarction targeted nanoparticle (CsA@HFn) was developed treat injury.CsA@HFn efficiently penetrated blood-brain barrier (BBB) selectively accumulated area, inhibiting opening mPTP production neuron. reduced damage BBB. Consequently, CsA@HFn significantly infarct area. Moreover, inhibited recruitment astrocytes region polarized into M2 type microglia, which alleviated inflammation.CsA@HFn showed a significant therapeutic effect on injury alleviating neuron, inflammation BBB has great potential stroke.