A thermoresponsive nanocomposite integrates NIR-II-absorbing small molecule with lonidamine for pyroptosis-promoted synergistic immunotherapy

• DOI: 10.1186/s12951-024-02424-5
• Publication Date: 2024-04-10T12:02:15Z
• Authors: Pengfei Chen; Chi Zhang; Liuliang He; Mingfei Li; Jie Rong; Pengfei Sun; Yingying Chen; Daifeng Li
• Keywords: Pyroptosis; Photothermal effect

Photothermal immunotherapy is regarded as the ideal cancer therapeutic modality to against malignant solid tumors; however, its benefits are often modest and require improvement. In this study, a thermoresponsive nanoparticle (BTN@LND) composed of photothermal agent (PTA) pyroptosis inducer (lonidamine) were developed enhance applications. Specifically, our "two-step" donor engineering strategy produced strong NIR-II-absorbing organic small-molecule PTA (BTN) that exhibited high NIR-II performance (ε