NIR-responsive electrospun nanofiber dressing promotes diabetic-infected wound healing with programmed combined temperature-coordinated photothermal therapy

• DOI: 10.1186/s12951-024-02621-2
• Publication Date: 2024-07-02T02:02:06Z
• Authors: Jinlang Fu; Ding Wang; Zinan Tang; Yixin Xu; Jiajun Xie; Rong Chen; Pinkai Wang; Qiang Zhong; Yanhong Ning; Mingyuan Lei; Huaming Mai; Hao Li; Haibing Liu; Jian Wang; Hao Cheng
• Keywords: Electrospinning; Wound dressing

Abstract Background Diabetic wounds present significant challenges, specifically in terms of bacterial infection and delayed healing. Therefore, it is crucial to address local issues promote accelerated wound In this investigation, we utilized electrospinning fabricate microgel/nanofiber membranes encapsulating MXene-encapsulated microgels chitosan/gelatin polymers. Results The film dressing facilitates programmed photothermal therapy (PPT) mild (MPTT) under near-infrared (NIR), showcasing swift extensive antibacterial biofilm-disrupting capabilities. PPT effect achieves prompt sterilization within 5 min at 52 °C disperses mature biofilm 10 min. Concurrently, by adjusting the NIR power induce heating (42 °C), stimulates fibroblast proliferation migration, significantly enhancing vascularization. Moreover, vivo experimentation successfully validates dressing, underscoring its immense potential addressing intricacies diabetic wounds. Conclusions MXene microgel-loaded nanofiber employs temperature-coordinated therapy, effectively amalgamating advantageous features high-temperature low-temperature promotion It exhibits rapid, broad-spectrum capabilities, exceptional biocompatibility, noteworthy effects on promoting cell These results affirm efficacy our highlighting challenge struggling heal due infection. Graphical