Impact of endometriosis on oocyte morphology in IVF-ICSI: retrospective study of a cohort of more than 6000 mature oocytes

• DOI: 10.1186/s12958-021-00798-x
• Publication Date: 2021-10-16T18:22:07Z
• Authors: Camille Robin; Audrey Uk; Christine Decanter; Hélène Behal; Pierre Collinet; Chrystèle Rubod; Anne-Laure Barbotin; Geoffroy Robin
• Keywords: Oocyte morphology; Adult; Male; QH471-489; Pregnancy Rate; [SDV]Life Sciences [q-bio]; Endometriosis; Fertilization in Vitro; Cohort Studies; 03 medical and health sciences; Oogenesis; 0302 clinical medicine; Oocyte quality; Pregnancy; In vitro fertilization; Humans; Endometrioma; Ovarian Diseases; Sperm Injections, Intracytoplasmic; Birth Rate; Cell Size; Retrospective Studies; Reproduction; Research; Infant, Newborn; Gynecology and obstetrics; Prognosis; 3. Good health; RG1-991; Oocytes; Female; France; Infertility, Female

Abstract Background Infertility associated with endometriosis can be explained by several non-exclusive mechanisms. The oocyte plays a crucial role in determining embryonic competence and this is particularly relevant for vitro fertilization (IVF) outcomes. According to some authors, the morphology of oocytes could also non-invasive marker quality. aim study was evaluate relationship between after controlled ovarian stimulation intracytoplasmic sperm injection (ICSI) on large cohort. Methods Single-center comparative retrospective academic In Vitro Fertilization unit Lille University Hospital. A total 596 women treated IVF-ICSI ejaculated spermatozoa alterations were included. They classified as (n = 175) or control groups 401). morphological evaluation 2,016 mature from 348 cycles patients compared that 4,073 576 cycles. main outcome measures Average Oocyte Quality Index (AOQI) metaphase II scoring system (MOMS). Comparison carried out mixed linear model generalized estimation equation "patient" random effect consider patient might have attempts. Results No difference AOQI MOMS scores found ( adjusted p 0.084 0.053, respectively). case endometriosis, there significantly fewer retrieved, embryos obtained, grade 1 number cumulative clinical pregnancies controls. group, surgery reduced presence endometrioma(s) abnormal shapes. Nevertheless, no concerning these subgroups. Conclusion Endometriosis does not negative impact oocytes’ IVF-ICSI. Trial registration On December 16, 2019, Institutional Review Board Hospital gave unrestricted approval anonymous use all patients’ clinical, hormonal ultrasound records (reference DEC20150715-0002).