Association between clinical and IVF laboratory parameters and miscarriage after single euploid embryo transfers

• DOI: 10.1186/s12958-021-00870-6
• Publication Date: 2021-12-14T06:02:36Z
• Authors: María del Carmen ...; María Cruz; Silvia de Frutos; Eva María Martínez; María Gaytán; Marta Ariza; Fernando Bronet; Juan A. Garcia-Ve...
• Keywords: Live birth; Unexplained infertility

Abstract Background The goal of this study was to investigate which factors, excluding embryo aneuploidies, are associated with miscarriage in patients who have undergone a single euploid blastocyst transfer. Methods Retrospective, observational and multicenter 2832 undergoing preimplantational genetic testing for aneuploidies (PGT-A) due repeated implantation failure, recurrent pregnancy loss, advanced maternal age or severe male factor were transferred one embryo. Results One the main findings significant relationship between body mass index (BMI) rates (13.4% underweight women, 12.1% normal weight, 14.5% overweight, 19.2% obese odds ratio [OD] 1.04; 95% confidence interval [CI], 1.01–1.07 p = 0.006). Endometrial thickness (OD 0.65; 95%, 0.52–0.77 0.04) type endometrial preparation (natural cycle hormone replacement cycle) 0.77; 0.52–0.77, also rates. Conclusions BMI strongly We observed weaker association cycle). None other studied variables (biopsy day, age, duration infertility, length, previous miscarriages, live births, In Vitro Fertilization (IVF) cycles, pattern and/or diagnosis)