Level of agreement between patient-reported EQ-5D responses and EQ-5D responses mapped from the SF-12 in an injury population

• DOI: 10.1186/s12963-015-0047-z
• Publication Date: 2015-06-12T06:31:49Z
• Authors: Belinda J Gabbe; Emma McDermott; Pam M Simpson; Sarah Derrett; Shanthi Ameratunga; Suzanne Polinder; Ronan A Lyons; Frederick P Rivara; James E Harrison
• Keywords: EQ-5D; Kappa; Depression; Cohen's kappa

Comparing health-related quality of life (HRQL) outcomes between studies is difficult due to the wide variety instruments used. study and facilitating pooled data analyses requires valid "crosswalks" HRQL instruments. Algorithms exist map 12-item Short Form Health Survey (SF-12) responses EQ-5D item preference weights, but none have been validated in populations where disability prevalent, such as injury.Data were extracted from Validating Improving injury Burden Estimates Study (Injury-VIBES) for 10,166 adult, hospitalized trauma patients, with both three-level (EQ-5D-3L) SF-12 at six 12-months postinjury. Agreement actual (patient-reported) estimated (mapped SF-12) EQ-5D-3L weights was assessed using Kappa, Prevalence-Adjusted Bias-Adjusted Kappa statistics Bland-Altman plots.Moderate agreement observed usual activities, pain/discomfort, anxiety/depression. substantial mobility self-care items. The mean differences -0.024 -0.012 12 months (p < 0.001), respectively. plot limits large compared range weight values (-0.56 1.00). Estimated under-reported all items except pain/discomfort.Caution should be taken when mapped describe patient or undertaking economic evaluation, underestimation associated values. findings this could used adjust expected combining that use either instrument.