Glutamine addiction in tumor cell: oncogene regulation and clinical treatment

• DOI: 10.1186/s12964-023-01449-x
• Publication Date: 2024-01-03T09:04:32Z
• Authors: Xian Li; Xueqiang Peng; Yan Li; Shibo Wei; Guangpeng He; Jiaxing Liu; Xinyu Li; Shuo Yang; Dai Li; Weikai Lin; Jianjun Fang; Liang Yang; Hangyu Li
• Keywords: 0303 health sciences; 03 medical and health sciences; Metabolism; Tumor; QH573-671; Glutamine; R; Medicine; Review; Cytology; Oncogene clinical treatment

Abstract After undergoing metabolic reprogramming, tumor cells consume additional glutamine to produce amino acids, nucleotides, fatty and other substances facilitate their unlimited proliferation. As such, the metabolism of is intricately linked survival progression cancer cells. Consequently, targeting presents a promising strategy inhibit growth cell development. This review describes uptake, metabolism, transport in its pivotal role biosynthesis more. Furthermore, we have also summarized impact oncogenes like C-MYC , KRAS HIF p53 on regulation mechanisms through which triggers mTORC1 activation. In addition, different anti-cancer agents has been described prospective applications are assessed.