Circulating resistin levels are early and significantly increased in deceased brain dead organ donors, correlate with inflammatory cytokine response and remain unaffected by steroid treatment

• DOI: 10.1186/s12967-015-0574-1
• Publication Date: 2015-06-25T13:55:10Z
• Authors: Rille Pullerits; Simona Oltean; Anne Flodén; Mihai Oltean
• Keywords: Resistin; Proinflammatory cytokine; Interleukin 18

Resistin is a pro-inflammatory adipokine that increases after brain injury (trauma, bleeding) and may initiate an inflammatory response. was found increased in deceased, dead organ donors (DBD) correlated with delayed graft function kidney transplantation. The kinetics of resistin during death (BD), its impact on the response influence several donor variables levels are still unknown.Resistin along panel Th1/Th2 cytokines [interferon (IFN)-gamma, interleukin (IL)-1beta, IL-2, IL-6, IL-8, IL10, IL-12, IL-13 tumor necrosis factor (TNF)] analyzed 36 DBDs diagnosis BD before procurement 12 living (LD). cytokine were relation to parameters including cause death, donors' age steroid treatment.Resistin higher both at compared LD (p < 0.001). had significantly IL-1beta, IL-10 TNF time points LD. In DBDs, positively IL-1beta (rs 0.468, p = 0.007), IL-6 0.511, 0.002), 0.372, 0.028), IL-12 0.398, 0.024), 0.397, 0.030) 0.427, 0.011) procurement. over 60 treatment did not affect levels. However, decreased IFN-gamma procurement.Resistin early remains throughout period correlates strongly mediators. level, contrast cytokines, affected by treatment. increase related but influenced or death. be one initial triggers for systemic activation seen DBDs.