Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study

• DOI: 10.1186/s12967-016-0941-6
• Publication Date: 2016-06-24T03:08:03Z
• Authors: Federica Rizzi; Costanza Conti; Elena Dogliotti; Annalisa Terranegra; Erika Salvi; Daniele Braga; Flavia Ricca; Sara Lupoli; Alessandra Mingione; Francesca Pivari; Caterina Brasacchio; Matteo Barcella; Martina Chittani; Francesca D’Avila; Maurizio Turiel; Monica Lazzaroni; Laura Soldati; Daniele Cusi; Cristina Barlassina
• Keywords: Paraoxonase

Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile susceptibility atherosclerosis cardiovascular disease. However, the interaction between these factors remains be investigated. We performed an observational nutrigenetic study examine whether anthocyanins PON1 genetic variants can modulate biomarkers of health in Italian healthy population. recruited 443 volunteers who participated EC funded ATHENA project (AnThocyanin bioactive for Health Enhancement through Nutritional Advancement). Data collection included detailed demographic, clinical, dietary, lifestyle, biochemical data. Polyphenols was measured by 24 h dietary recall repeated three times a year order get seasonal variations. tested 18 independent tagging SNPs on HDL, LDL, cholesterol, triglycerides atherogenic index plasma. Without considering background, we could not observe significant differences high low intake. Using approach, identified protective genotypes four that, at Bonferroni level (p ≤ 0.0028), present association with increased HDL under intake, compared risk (rs854549, Beta = 4.7 per C allele; rs854552, 5.6 rs854571, 3.92 T rs854572, 3.94 allele). highlight role towards consumption. represent novel stratify individuals might benefit from targeted recommendation promotion strategies preventive medicine.