Benefits of local tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database

• DOI: 10.1186/s12967-017-1204-x
• Publication Date: 2017-05-30T13:28:08Z
• Authors: Jian Sun; Zhongying Huang; Zheyu Hu; Rui Sun
• Keywords: Adult; Male; Propensity score; Databases, Factual; Kaplan-Meier Estimate; 03 medical and health sciences; 0302 clinical medicine; Pharyngectomy; Nasopharyngeal carcinoma (NPC); Ethnicity; Humans; Propensity Score; Aged; Neoplasm Staging; Proportional Hazards Models; Retrospective Studies; Nasopharyngeal Carcinoma; Radiotherapy; Research; Carcinoma; R; Epidemiology and End results (SEER) database; Nasopharyngeal Neoplasms; Middle Aged; 3. Good health; Treatment Outcome; Medicine; Female; Local tumor excision; SEER Program

There is ongoing debate about surgery of primary site in nasopharyngeal carcinoma patients. 3919 patients with identified the SEER registry between 2004 and 2013. The benefit nasopharynx tumor on overall cancer-specific survival was assessed by risk-adjusted multivariate Cox proportional hazard regression propensity score matching modeling. Surgery marginally associated better (hazard ratio (HR) = 0.816, 95% CI 0.656–1.015, p 0.07) (HR 0.749, 0.552–1.018, 0.06) model. Among 398 cases who underwent surgery, 282 (70.85%) received local excision 79 (20.31%) pharyngectomy. Local pharyngectomy had almost same effect analysis. significant subgroups white, age <60 year, T3, N1, M0, AJCC stage III, or moderately differentiated tumors. Further analysis showed to promote both radiotherapy non-radiotherapy This first population-based using model provide evidence a positive impact carcinoma. Moreover, demonstrated specific clinical characteristics.