RETRACTED ARTICLE: TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/β-catenin pathway
Male
Esophageal Neoplasms
Carcinogenesis
Proliferation
Down-Regulation
Mice, Nude
Apoptosis
03 medical and health sciences
Cell Line, Tumor
Wnt/β-catenin pathway
Animals
Humans
Neoplasm Invasiveness
Wnt Signaling Pathway
Aged
Cell Proliferation
Mice, Inbred BALB C
0303 health sciences
Research
R
Intracellular Signaling Peptides and Proteins
Middle Aged
Xenograft Model Antitumor Assays
TIPE2
3. Good health
Gene Expression Regulation, Neoplastic
Esophageal carcinoma
Tumorigenesis
Disease Progression
Medicine
Female
DOI:
10.1186/s12967-018-1383-0
Publication Date:
2018-01-17T12:25:08Z
AUTHORS (16)
ABSTRACT
Abstract Background Esophageal carcinoma is the eighth prevalent malignancy and ranks sixth in carcinoma-related death worldwide. Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) has been identified as a tumor suppressor multiple carcinomas. However, its roles molecular mechanisms underlying esophageal progression are still undefined till now. Methods RT-qPCR assay was employed to detect expression of TIPE2 mRNA. protein measured by using western blot assay. Ad-V Ad-TIPE2 adenoviruses were constructed overexpress TIPE2. The effects overexpression on cell proliferation, invasion apoptosis assessed MTT Edu incorporation assays, transwell flow cytometry analysis, respectively. effect xenograft growth determined measuring volume weight, together with immunohistochemistry Wnt/β-catenin signaling pathway evaluated detecting levels β-catenin, c-Myc cyclinD1 EC9076 cells tumors carcinoma. Results downregulated tissues cells. Adenovirus-mediated suppressed proliferation invasion, induced Enforced inhibited vivo, evidenced reduced volume, weight proliferating nuclear antigen expression. Overexpression vitro vivo. Conclusions These results suggest that tumorigenesis via inhibition pathway.
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