Exosomes derived from myeloid-derived suppressor cells facilitate castration-resistant prostate cancer progression via S100A9/circMID1/miR-506-3p/MID1

• DOI: 10.1186/s12967-022-03494-5
• Publication Date: 2022-08-02T11:18:15Z
• Authors: Feng Gao; Qiaoping Xu; Zhe Tang; Nan Zhang; Yasheng Huang; Zhongyi Li; Yuliang Dai; Qiqi Yu; Jingyu Zhu
• Keywords: Tumor progression; Myeloid-derived Suppressor Cell; S100A9

Castration-resistant prostate cancer (CRPC) is a major cause of recurrence and mortality among (PCa) patients. Myeloid-derived suppressor cells (MDSCs) regulate castration resistance in PCa. Previously, it was shown that intercellular communication efficiently mediated by exosomes (Exos), but the role mechanism MDSC-derived Exos CRPC progression unclear.In this study, circRNA expression profiles PC3 treated with MDSC-Exo control were investigated using microarray.The data showed circMID1 (hsa_circ_0007718) elevated MDSC-Exo. Moreover, high found PCa compared benign prostatic hyperplasia (BPH) tissues patients hormone sensitive (HSPC) Further studies accelerated cell proliferation, migration, invasion, while deficiency inhibited MDSC-Exo-regulated vitro vivo. Mechanistically, exosomal S100A9 increased to sponge miR-506-3p, leading MID1 tumor progression.Together, our results S100A9/circMID1/miR-506-3p/MID1 axis existed progression, which provided novel insights into regulatory mechanisms progression.