Genetically predicted testosterone and cancers risk in men: a two-sample Mendelian randomization study

• DOI: 10.1186/s12967-022-03783-z
• Publication Date: 2022-12-08T12:02:59Z
• Authors: Junke Chang; Yongming Wu; Sicheng Zhou; Ye Tian; Yan Wang; Jie Tian; Wenpeng Song; Yinxian Dong; Jue Li; Ziyi Zhao; Guowei Che
• Keywords: Mendelian Randomization

In observational studies, testosterone has been reported to be associated with some types of cancers. However, the direction and magnitude causal association between different cancer remain unclear. This Mendelian randomization study assessed associations total (TT) bioavailable (BT) risk in men.We performed two-sample using publicly available GWAS summary statistics investigate genetically 22 kinds cancers men. Causal estimates were calculated by inverse variance weighted method. We also additional sensitivity tests evaluate validity casualty.Genetically predicted BT level significantly an increased prostate [odds ratio (OR) = 1.17 95% confidence interval (CI): 1.09-1.26, P 2.51E-05] MR analysis IVW TT was found suggestive protective factor against stomach (OR 0.66, CI: 0.48-0.93, 0.0116) as well pancreatic 0.59, 0.36-0.96, 0.0346). A occurrence small intestine 1.0004, 1.0001-1.0007, 0.0116). had no significant other cancers.This investigated role development cancer, but strong