Prognostic value of cardiovascular magnetic resonance derived right ventricular function in patients with interstitial lung disease

• DOI: 10.1186/s12968-015-0113-5
• Publication Date: 2015-02-10T09:33:09Z
• Authors: Shingo Kato; Akimasa Sekine; Yuka Kusakawa; Takashi Ogura; Masaaki Futaki; Tae Iwasawa; Hidekuni Kirigaya; Daiki Gyotoku; Naoki Iinuma; Kohei Iguchi; Tatsuya Nakachi; Kazuki Fukui; Kazuo Kimura; Satoshi Umemura
• Keywords: Angiology

Cardiovascular magnetic resonance (CMR) provides non-invasive and more accurate assessment of right ventricular (RV) function in comparison to echocardiography. Recent study demonstrated that RV by echocardiography was an independent predictor for mortality patients with interstitial lung disease (ILD). The purpose this determine the prognostic significance CMR derived ejection fraction (RVEF) ILD patients. We enrolled 76 24 controls current study. By using 1.5 T scanner equipped 32 channel cardiac coils, we performed steady-state free precession cine assess RVEF. systolic dysfunction (RVSD) defined as RVEF ≤45.0% calculated long axis slices. Pulmonary hypertension (PH) mean pulmonary artery pressure (mPAP) than 25 mmHg at rest setting capillary wedge ≤15 mmHg. median 59.2% (n = 24), 53.8% without PH 42) 43.1% 13) (p < 0.001 one-way ANOVA). During a follow-up 386 days, 18 RVSD had 11 severe events (3 deaths, 3 heart failure, exacerbation dyspnea requiring oxygen, 2 pneumonia hospitalization). In contrast, only oxygen were observed 58 RVSD. Multivariate Cox regression analysis showed independently predicted future events, after adjusting age, sex RVFAC (hazard ratio: 0.889, 95% confidence interval: 0.809 – 0.976, p 0.014). can be clearly detected CMR. Importantly, low prevalence (17%) indicated population included many mild might useful risk stratification clinical management